Atomoxetine: Uses, Interactions, Mechanism of Action

As part of a comprehensive therapy strategy that often includes psychological, social, and other treatments, Atomoxetine treats attention-deficit hyperactivity disorder (ADHD). As a result, the capacity to pay attention, concentrate, maintain focus, and refrain from fidgeting may be improved. It is believed to function by reestablishing the proper balance of a few natural chemicals (neurotransmitters) in the brain.

What is the usage and dosage of Atomoxetine?

Strattera alters brain and nerve chemicals involved in impulse control and hyperactivity. Attention, Deficit Hyperactivity Disorder is treated with the drug Strattera (ADHD).

Attention-Deficit/Hyperactivity Disorder Standard Adult Dose:

• The oral first dose of 40 mg every day.
• Maintenance Dose: After taking the first dose for at least three days, orally increase the dosage to 80 mg/day.
• Maximum Dose: In patients who have not seen an ideal response after an additional 2 to 4 weeks, the dose may be raised to 100 mg/day.
• Take one dosage in the morning each day.

For attention deficit disorder in children, the typical dosage is:

Less than 70 kg:

• The oral first dose of 0.5 mg/kg every day.
• Maintenance dosage: After taking the first dose for at least three days, increase the dose to 1.2 mg/kg/day.
• 4 mg/day or 100 mg/day, whichever is less, is the maximum dosage.

Beyond 70 kg:

• The oral first dose of 40 mg every day.
• Maintenance dose: After taking the first dose for at least three days, increase the dosage to 80 mg/day.
• Maximum dosage: In patients who have not seen an ideal response after an additional 2 to 4 weeks, the dose may be raised to 100 mg/day.
• Take the prescribed dose in the morning OR two equally spaced doses in the late afternoon/early evening.

Mechanism of Action

The norepinephrine transporter (NET) is known to be firmly and selectively inhibited by Atomoxetine, which is hypothesized to reduce the symptoms of ADHD by preventing norepinephrine from being reabsorbed by cells in the brain. In addition, a role for the glutamatergic system in the pathophysiology of ADHD has been shown more recently by positron emission tomography (PET) imaging studies in rhesus monkeys that revealed Atomoxetine also binds to the serotonin transporter (SERT) and inhibits the N-methyl-d-aspartate (NMDA) receptor.

Side Effects of Atomoxetine

There may be stomach discomfort, nausea, vomiting, constipation, fatigue, appetite loss or weight loss, dry mouth, dizziness, sleepiness, difficulty falling asleep, or a reduction in sexual ability or desire. Menstrual cramps or missing or irregular periods in women can also happen.

Get out of a sitting position carefully to reduce the risk of dizziness. Remember that your doctor has recommended this medicine because they believe it will help you more than harm you. Many users of this medicine report no significant adverse effects.

Your blood pressure may increase if you use this medicine. Regularly check your blood pressure, and let your doctor know if the readings are excessive.

Rarely, Atomoxetine may lead to significant (and perhaps deadly) liver damage. Therefore, you should seek medical attention immediately if you have any liver damage symptoms, such as persistent nausea, vomiting, lack of appetite, stomach or abdominal discomfort, or yellowing of the skin or eyes.

Precautions

If you have allergies, before taking it, talk to your physician. Inactive chemicals in this product can trigger allergic reactions or other issues. To learn more, speak with your pharmacist.

Tell your doctor or pharmacist about all of your medical histories before taking this medication, especially if any of the following conditions: high blood pressure, liver disease, glaucoma, a specific adrenal disorder (pheochromocytoma), bladder or prostate issues, glaucoma, heart problems (such as irregular heartbeat, heart failure, previous heart attack, problems with heart structure), personal/family history of mental/mood disorders (such as sudden cardiac death, irregular heartbeat), high blood pressure, and heart.

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